Treatment-resistant epilepsy

What it is

Epilepsy is called treatment-resistant (or drug-resistant) when seizures continue despite the correct use of at least two well-chosen, well-tolerated anti-seizure medications. This happens to about one in three people with epilepsy and can weigh heavily on development, independence and the whole family's routine.

How medical cannabis may be considered

Cannabidiol (CBD) may be added to existing treatment to help reduce how often seizures occur in some syndromes. It is introduced gradually, together with the neurologist, and requires attention to interactions with other anti-seizure medications, such as clobazam and valproate.

What treatment aims for

• Reduce how often and how intensely seizures occur, alongside current treatment.
• Improve sleep and quality of life for the person and their family.
• Do this safely, keeping track of interactions with other anti-seizure medications.

Important precautions

• Never stop or reduce anti-seizure medication on your own: every change is agreed with the neurologist.
• CBD can interact with medications such as clobazam and valproate; blood tests, such as liver enzymes, may be requested.
• A seizure diary (number, duration and time of day) is the best way to assess the response.